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Stress is a part of life, even on the cellular level. To survive and adapt to stresses such as nutrient deprivation or temperature shock, cells have to alter gene expression, especially protein translation, and alterations in these responses have been implicated in multiple human pathologies,…
We are studying how nutrients regulate signaling and transcription by O-GlcNAcylation (OGN). OGN is the addition and removal of N-acetylglucosamine from Ser(The) residues of nuclear, cytoplasmic and mitochondrial proteins. The cycling sugar is analogous to phosphorylation and has extensive…
We are using human pluripotent stem cells (human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs)) to differentiate cell types that are affected in diseases of the peripheral nervous system (PNS). Because primary patient PNS cells in large numbers are nearly…
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