Skip to main content
Skip to main menu

Slideshow

Hart

We are studying how nutrients regulate signaling and transcription by O-GlcNAcylation (OGN). OGN is the addition and removal of N-acetylglucosamine from Ser(The) residues of nuclear, cytoplasmic and mitochondrial proteins. The cycling sugar is analogous to phosphorylation and has extensive crosstalk with phosphorylation, both in terms of site occupancy and in the regulation of kinases. 

Current Projects:

  1. Roles of OGN in regulation of transcription, particularly on basal machinery and on RNA polymerase II
  2. Develop Optogenetic methods to target the O-GlcNAc transferase to specific substrates.
  3. Roles of OGN in diabetes and glucose toxicity. 
  4. Roles of OGN in regulation of protein translation and in mRNA selection. 
  5. Interplay between Src kinase and OGN in cancer. 
  6. Roles of OGN in Alzheimer's Disease.

Support us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.