Distinguished Research Professor, Adjunct CCRC Member Member of the Center for Tropical and Emerging Global Diseases Adjunct Professor of Microbiology Education Education: B.S. with Honors in Chemistry, University of Florida, 1973 Ph.D., NSF Pre-doctoral Fellow in Cell Biology, Caltech, 1978 American Cancer Society Post-doctoral Fellow, University of Pennsylvania, 1977-79 Research Research Areas: Glycobiology Developmental Biology Medicinal Chemistry & Chemical Biology Structural Biology Labs: West Selected Publications Selected Publications: All publications:see: http://www.ncbi.nlm.nih.gov/sites/myncbi/1LOb8OnUO-7kI/bibliography/40443676/public/?sort=date&direction=ascendingRecent publications (2014–): Xu, X., A. Eletsky, M.O. Sheikh, J.H. Prestegard & C.M. West (2018) Glycosylation promotes the random coil to helix transition in a region of a protist Skp1 associated with F-box binding. Biochemistry 57:511-515Sheikh, M.O., D. Thieker, G. Chalmers, C.M. Schafer, M. Ishihara, P. Azad2, R.J. Woods, J.N. Glushka, B. Bendiak, J.H. Prestegard & C.M. West (2017) O2 sensing–associated glycosylation exposes the F-box–combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases. J. Biol. Chem. 292:18897-18915. PMCID: PMC5704474West, C.M. & G.W. Hart (2017) Nucleocytoplasmic Glycosylation. In: Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A.G., Kinoshita, T., Packer, N.H., Prestegard, J.H., Schnaar, R.L., Seeberger, P.H., editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor Laboratory Press; Chapter 18.West, C.M. (2015) The 2015 Karl Meyer Lectureship Award and the Rosalind Kornfeld Award for Lifetime Achievement in Glycobiology, from the Society for Glycobiology. Glycobiology 25:1137-1138.Rahman, K., M. Mandalasi, P. Zhao, M.O. Sheikh, R. Taujale, H.W. Kim, H. van der Wel, K. Matta, N. Kannan, J.N. Glushka, L. Wells & C.M. West (2017) Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit. J. Biol. Chem. 292:18644-18659. PMCID: PMC5682971Taylor-Mulneix, D.L., L. Bendor, B. Linz, I. Rivera, V.E. Ryman, K.K. Dewan, S.M. Wagner, E.F. Wilson, L.J. Hilburger, L.E. Cuff, C.M. West & E.T. Harvill (2017) Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector. PLoS Biol. 15:e2000420. PMCID: PMC5389573Sheikh, M.O., S.M. Halmo, S. Patel, D. Middleton, H. Takeuchi, C.M. Schafer, C.M. West, R.S. Haltiwanger, F.Y. Avci, K.W. Moremen & L. Wells (2016) Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases. Glycobiology 27:206-212Summers, J.A., A.R. Harper, C.L. Feasley, H. van der Wel, J.N. Byrum, M. Hermann & C.M. West (2016) Identification of apolipoprotein A-1 as a retinoic acid binding protein in the eye. J. Biol. Chem. 291:18991-19005. PMCID: PMC5009271Bergstrom, K., X. Liu, Y. Zhao, N. Gao, Q. Wu, K. Song, Y. Cui, Y. Li, J.M. McDaniel, S. McGee, W. Chen, M.M. Huycke, C.W. Houchen, L.A. Zenewicz, C.M. West, H. Chen, J. Braun, J. Fu & L. Xia (2016) Defective intestinal mucin-type O-glycosylation causes spontaneous colitis-associated cancer in mice. Gastroenterology 151:152-164. PMCID: PMC5068133Rahman K., P. Zhao, M. Mandalasi, H. van der Wel, L. Wells, I.J. Blader & C.M. West (2016) The E3-ubiquitin ligase adaptor protein Skp1 is glycosylated by an evolutionarily conserved pathway that regulates protist growth and development. J. Biol. Chem. 291:4268-4280. PMCID: PMC4813455 *Designated ‘Paper of the Week’West, C.M. & I.J. Blader (2015) Oxygen sensing by protozoans: How they catch their breath. Curr. Opin. Microbiol. 26:41-47Sheikh, M.O., Y Xu, H. van der Wel, P. Walden, S.D. Hartson & C.M. West (2015) Glycosylation of Skp1 promotes formation of Skp1/Cullin-1/F-box protein complexes in Dictyostelium. Mol. Cell. Proteomics 14:66-80. PMC4288264Weigel, P.H., C.M. West, P. Zhao, L. Wells, B.A. Baggenstoss & J.L. Washburn (2015) Hyaluronan synthase assembles chitin oligomers with –GlcNAc(α1–)UDP at the reducing end. Glycobiology 25:632-643 (PMC4410831)Feasley, C.L., H. van der Wel & C.M. West (2015) Evolutionary diversity of social amoebae N-glycomes may support interspecific autonomy. Glycoconjugate J. 32:345–359.Chinoy, Z.S., C.M. Schafer, C.M. West & G.-J. Boons (2015) Chemical synthesis of a glycopeptide derived from Skp1 for probing protein specific glycosylation. Chemistry – A European Journal 21:11779-11787 (PMC4646072)Koeller, C.M., H. van der Wel, C.L. Feasley, F. Abreu, F. Montalvão, P. Fampa, F.C.G. dos Reis, G.C. Atella, T. Souto-Padrón, C.M. West* & N. Heise* (2014) Non-enzymatic function of UDP-GlcNAc:polypeptide O-α-N-acetyl-D-glucosaminyltransferase-2 (TcOGNT2) regulates metacyclogenesis in Trypanosoma cruzi. Eukaryotic Cell 13:1312-1327. *co-corresponding authors (PMC4187647)Karunaratne, C.V., T. Weldeghiorghis, C.M. West & C.M. Taylor (2014) Conformational changes associated with post-translational modifications of Pro143 in Skp1 of Dictyostelium- a dipeptide model system. J. Am. Chem. Soc. 136:15170-15175 (PMC4227711)West, M.B., K. Partyka, C.L. Feasley, K.A. Maupin, I. Goppallawa, C.M. West, B.B. Haab & M.H. Hanigan (2014) Detection of distinct glycosylation patterns on human γ-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology. BMC Biotechnology 14:101 (PMC4297448)Pan, Y., T. Yago, J. Fu, B. Herzog, J.M. McDaniel, P. Mehta-D’Souza, C. Ruan, R.P. McEver, C.M. West, K. Dai, H. Chen & L. Xia (2014) Podoplanin requires sialylated O-glycan for stable expression on lymphatic endothelial cells and for interaction with platelets. Blood 124:3656-3665 (PMC4256915)Schafer, C.M., M.O. Sheikh, D. Zhang & C.M. West (2014) Novel regulation of Skp1 by the Dictyostelium AgtA α-galactosyltransferase involves the Skp1-binding activity of its WD40-repeat domain. J. Biol. Chem. 289:9076-9088 (PMC3979368)Sheikh, M.O., C.M. Schafer, J.T. Powell, K.K. Rodgers, B.H.M. Mooers & C.M. West (2014) Glycosylation of Skp1 affects its conformation and promotes binding to a model F-box protein. Biochemistry 53:1657-1669. (PMC3985704)West, C.M., H. van der Wel, Z. Chinoy, G.-J. Boons, T.J. Gauthier, C.M. Taylor & Y. Xu (2014) Generating isoform-specific antibodies: lessons from the nucleocytoplasmic glycoprotein Skp1. In: Glycoscience: Biology and Medicine. Eds.: N. Taniguchi, T. Endo, G. Hart, P. Seeberger, C.-H. Wong. (Springer), pp. 927-934. Courses Regularly Taught Courses Regularly Taught: BCMB 4010 (Undergraduate) / BCMB 6010 (Graduate) BCMB 8060 Of Note Of note: Current outside activities: Editorial Board member: BBA General Subjects, GlycobiologyBoard Member: Association of Medical and Graduate Departments of BiochemistryNIH Study Section reviewer, ad hoc Grants Grants: Extramural funding (as PI): NIH 5 R01 GM-037539-25; Cytosolic proline hydroxylation and glycosylation (2013-2018)NIH 2R01 GM-084383-07 (with I. Blader); Glycoregulation of Skp1 in the cytoplasm and nucleus (2015-2019)NIH 1R21 AI-123161-01 (with R. Tarleton, L. Wells); Enabling tools for protist pathogen glycobiology (2015-2018)NIH 2R01AI069986-12 (subcontract to I.J. Blader); Control of Toxoplasma gondii Growth by the Host Cell Transcription Factor HIF1 (2017-2020) Recent past funding (as PI):NIH 1R21 AI-109643-01 (with I. Blader); Role of rolyl hydroxylation in Toxoplasma oxygen sensing (2015-2017)NIH 1R03TW008725-04 (Fogarty); Role of mucin-type O-glycosylation in Trypanosoma cruzi (2011-2014)NIH 1S06GM110786 (Indian Health Services); Oklahoma NARCH Student Development Program- NARCH VIII (2014-2015)Mizutani Foundation for Glycoscience 14-140; Role of cytoplasmic glycans in protozoan oxygen sensing (2015)
