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Seminar: Dr. Vanessa Sperandio, "The Highs and Lows of Enteric Infections"

Jane and Bud Smith Distinguished Chair in Medicine
Microbiology | Biochemistry
UT Southwestern Medical Center
C127 Davison Life Sciences and Zoom
Special Information:
Zoom link:

Reception at 3:30 p.m., seminar at 4 p.m.

Research in the Sperandio laboratory is directed toward understanding how bacteria recognize the host, and how we can exploit this knowledge to interfere with bacterial infections. My laboratory reported that bacterial pathogens, such as enterohemorrhagic E. coli (EHEC), Salmonella typhimurium, Francisella tularensis, typical of the “super bugs”, exploit cell-to-cell signaling between the microbial flora and the host as a means to gage and recognize the host environment. This inter-kingdom signaling is predicated upon hormonal communication, and utilizes the host epinephrine and/or norepinephrine (NE) stress hormones and a bacterial aromatic hormone-like signal named autoinducer-3 (AI-3).

- from Dr. Sperandio's lab homepage

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