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Proteomics / Genomics / Bioinformatics / Metabolomics

Labs associated with

Our current research focuses mainly on hyperthermophiles, which are microorganisms that grow near 100°C, and on the roles of metals in microbial metabolism.  In a basic science project, we are using the archaeon Pyrococcus furiosus, which grows up to 103°C, to study the structure and evolution…

The Edison lab develops new approaches in metabolomics and natural products research. Our primary research tool is NMR spectroscopy, but we regularly collaborate with experts in mass spectrometry. A major focus is on data integration between NMR, MS, and other quantitative measurements. We have…

Our research concerns the mechanism and consequences of Ty1 retrotransposition in the budding yeast Saccharomyces. The Ty1 life cycle resembles that of retroviruses except transposition is not infectious. Ty1 GAG and POL genes encode the structural and enzymatic proteins required for…

My laboratory is interested in the molecular and biochemical basis of parasitic diseases.  We are currently studying African trypanosomes which are important protozoan parasites causing human African sleeping sickness and Nagana in cattle.  We have made important contributions to the…

We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work. Our current efforts are focused on protein kinases, a large and diverse…

The primary focus of the Pierce laboratory centers on understanding the regulation of intercellular recognition and adhesion, particularly those events that involve protein-oligosaccharide interactions. Almost 20 years ago, observations were made that when vertebrate cells became oncogenically…

The three dimensional structures of proteins or protein complexes can provide important clues concerning protein function and mechanism of action on a molecular level. The Rose laboratory is interested in using molecular biology coupled with X-ray crystallography and other biophysical techniques…

Our research focuses on protein structure and function and protein-protein interactions. We employ an approach combining modern analytical, biophysical and molecular biology techniques, with an emphasis on biomolecular NMR spectroscopy. Our core projects include the study of gene regulation and…

Functional diversity increases as you go from DNA to RNA to Proteins. The concept of one gene encodes one gene product is no longer valid. One of the principle ways that diversity is increased is through post-translational modifications of proteins.

Using a combination of methodologies,…

Research in the Woods group examines the relationship between carbohydrate conformation and biological recognition. Areas of particular interest include carbohydrate antigenicity in immunological events, carbohydrate- processing enzymes, and the development of appropriate simulational methods…

Study of Microbial Genome Structure and Application to Pathway & Network Inference:

We are interested in understanding both the micro- and macro-structures of microbial genomes through computational studies and experimental validation, and in understanding why microbial genomes are organized…

We study stem cells in skeletal muscle and adipose (fat) tissues and develop therapeutics for muscular dystrophy, muscle atrophy, obesity, and type 2 diabetes. We use transgenic mice and cultured human cells to model human diseases and identify therapeutic agents/approaches.

My lab is using experimental and computational approaches to study genomic and epigenomic changes occurring during cancer initiation and progression, as well as during normal biological processes such as mammalian genome evolution and cell differentiation. The goal is to understand the roles of…

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