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Nucleic Acid Biochemistry / Gene Expression

Labs associated with

Our research concerns the mechanism and consequences of Ty1 retrotransposition in the budding yeast Saccharomyces. The Ty1 life cycle resembles that of retroviruses except transposition is not infectious. Ty1 GAG and POL genes encode the structural and enzymatic proteins required for…

My laboratory is interested in the molecular and biochemical basis of parasitic diseases.  We are currently studying African trypanosomes which are important protozoan parasites causing human African sleeping sickness and Nagana in cattle.  We have made important contributions to the…

The work in my laboratory deals with the biosynthesis of heme and it regulation. Heme is an essential cofactor for almost all living organisms and participates in a variety of reactions including the regulation central metabolic processes, oxygen binding and transport and reduction/oxidation…

Antigenic variation in African trypanosomes

Among the parasites we currently study in the laboratory are African trypanosomes, unicellular eukaryotic protozoa that infect the bloodstream of mammals to cause sleeping sickness in equatorial Africa. Trypanosomiasis continues to be a daily…

We study CRISPR-Cas immune systems that protect prokaryotes from viruses and provide research tools for important biotechnology and biomedical applications

CRISPR-Cas systems are recently discovered RNA-based adaptive immune systems that control invasions of viruses and other mobile…

Our research focuses on protein structure and function and protein-protein interactions. We employ an approach combining modern analytical, biophysical and molecular biology techniques, with an emphasis on biomolecular NMR spectroscopy. Our core projects include the study of gene regulation and…

Functional diversity increases as you go from DNA to RNA to Proteins. The concept of one gene encodes one gene product is no longer valid. One of the principle ways that diversity is increased is through post-translational modifications of proteins.

Using a combination of methodologies,…

We study stem cells in skeletal muscle and adipose (fat) tissues and develop therapeutics for muscular dystrophy, muscle atrophy, obesity, and type 2 diabetes. We use transgenic mice and cultured human cells to model human diseases and identify therapeutic agents/approaches.

My lab is using experimental and computational approaches to study genomic and epigenomic changes occurring during cancer initiation and progression, as well as during normal biological processes such as mammalian genome evolution and cell differentiation. The goal is to understand the roles of…

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