Postdoctoral Fellow, Garfinkel Lab Sean Beckwith (he/him/his) is a postdoc with David Garfinkel interested in the biology of mobile genetic elements and mechanisms utilized in natural systems to control the movement of these elements. He received his Ph.D. from Stanford University in 2018 and his B.A. from Carleton College in 2012. His doctoral work with Ashby Morrison focused on the interplay between epigenetics and metabolic signaling. He currently investigates the virus-like Ty1 retrotransposon in the budding yeast Saccharomyces supported by an NIH F32 postdoctoral fellowship. Education Education: Ph.D., Stanford University, 2018 B.A., Carleton College, 2012 Research Labs: Garfinkel Selected Publications Selected Publications: Beckwith S, Nomberg E, Newman A, Taylor J, Guerrero R, Garfinkel D. An interchangeable prion-like domain is required for Ty1 retrotransposition. bioRxiv. 2023. doi.org/10.1101/2023.02.27.530227. Cottee M#, Beckwith S#, Letham S, Kim S, Young G, Stoye J, Garfinkel D, Taylor A. Structure of a Ty1 Restriction Factor Reveals the Molecular Basis of Transposition Copy Number Control. Nature Communications. 2021. doi:10.1038/s41467-021-25849-0. Beckwith S, Schwartz E, Garcia-Nieto P, King A, Gowans G, Wong K, Yao W, Eckley T, Paraschuk A, Peltan E, Lee L, Morrison AJ. The INO80 Chromatin Remodeler Sustains Metabolic Stability by Promoting TOR Signaling and Regulating Histone Acetylation. PLoS Genetics. 2018. doi:10.1371/journal.pgen.1007216. Zhou C#, Johnson S#, Lee L, Longhurst A, Beckwith S, Johnson M, Morrison A, and Narlikar G. The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding. Molecular Cell. 2018. doi:10.1016/j.molcel.2018.01.028. Yao W#, King D#, Beckwith S, Gowans G, Yen K, Zhou C, and Morrison AJ. The INO80 Complex Requires the Arp5- Ies6 Subcomplex for Chromatin-Remodeling and Metabolic Regulation. Molecular and Cellular Biology. 2016. doi:10.1128/MCB.00801-15. Yao W, Beckwith S, Zheng T, Young T, Dinh V, Ranjan A, and Morrison AJ. Assembly of the Arp5 Subunit Involved in Distinct INO80 Chromatin-Remodeling Activities. The Journal of Biological Chemistry. 2015. doi:10.1074/jbc.M115.674887. # = co-first author Other Website Other Website: LinkedIn ORCID @SeanLBeckwith Grants Grants: NIH F32 Ruth L. Kirschstein National Research Service Award (NRSA)
