Labs

The group has a general interest in anaerobic microorganisms, particularly archaea and particularly those growing near and above 100°C, the so-called hyperthermophiles. The archaeon Pyrococcus furiosus and the bacterium Thermotoga maritima are being used as model systems. Projects involve the…
The Edison lab develops new approaches in metabolomics and natural products research. Our primary research tool is NMR spectroscopy, but we regularly collaborate with experts in mass spectrometry. A major focus is on data integration between NMR, MS, and other quantitative measurements. We have…

Our research concerns the mechanism of Ty1 element retrotransposition and copy number control in the budding yeast Saccharomyces. Ty elements comprise five related families of long terminal repeat (LTR) retrotransposons that transpose through an RNA intermediate. The Ty life cycle resembles that…
My laboratory is interested in the molecular and biochemical basis of parasitic diseases.  We are currently studying African trypanosomes which are important protozoan parasites causing human African sleeping sickness and Nagana in cattle.  We have made important contributions to the understanding…
We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work. Our current efforts are focused on protein kinases, a large and diverse family…
The primary focus of the Pierce laboratory centers on understanding the regulation of intercellular recognition and adhesion, particularly those events that involve protein-oligosaccharide interactions. Almost 20 years ago, observations were made that when vertebrate cells became oncogenically…
The three dimensional structures of proteins or protein complexes can provide important clues concerning protein function and mechanism of action on a molecular level. The Rose laboratory is interested in using molecular biology coupled with X-ray crystallography and other biophysical techniques to…
Our research focuses on protein structure and function and protein-protein interactions. We employ an approach combining modern analytical, biophysical and molecular biology techniques, with an emphasis on biomolecular NMR spectroscopy. Our core projects include the study of gene regulation and…
Functional diversity increases as you go from DNA to RNA to Proteins. The concept of one gene encodes one gene product is no longer valid. One of the principle ways that diversity is increased is through post-translational modifications of proteins.
Using a combination of methodologies, including…
Research in the Woods group examines the relationship between carbohydrate conformation and biological recognition. Areas of particular interest include carbohydrate antigenicity in immunological events, carbohydrate- processing enzymes, and the development of appropriate simulational methods for…
Study of Microbial Genome Structure and Application to Pathway & Network Inference:
We are interested in understanding both the micro- and macro-structures of microbial genomes through computational studies and experimental validation, and in understanding why microbial genomes are organized…
Dr. York's diverse research interests include the development and application of spectroscopic and computational methods for the structural and conformational analysis of complex carbohydrates, the development of bioinformatics tools to study the roles of carbohydrates in living systems, and the…
My lab is using experimental and computational approaches to study genomic and epigenomic changes occurring during cancer initiation and progression, as well as during normal biological processes such as mammalian genome evolution and cell differentiation. The goal is to understand the roles of…