Labs

The Dalton laboratory is interested in how ‘molecular medicine’ can be used to understand human disease, for the purpose of developing new therapies and cures.
Pluripotent stem cells are being in the Dalton laboratory to decipher the molecular and cellular basis of human disease and to understand…

Our research concerns the mechanism of Ty1 element retrotransposition and copy number control in the budding yeast Saccharomyces. Ty elements comprise five related families of long terminal repeat (LTR) retrotransposons that transpose through an RNA intermediate. The Ty life cycle resembles that…
Short Biography:
Dr. Haltiwanger received his B.S. in Biology (1980) and Ph.D. in Biochemistry (1986) from Duke University. He went on to do postdoctoral work at Johns Hopkins University School of Medicine, and took his first independent position as an Assistant Professor in the Department of…
The primary goal of our research is to understand the molecular basis of self-renewal and differentiation in normal and cancer stem cells.  Currently we focus on hematopoiesis as a system to uncover the cellular machinery that regulates homeostasis and regeneration in bone marrow as well as to…
We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work. Our current efforts are focused on protein kinases, a large and diverse family…
Biosynthesis and Biological Function of Pectin
What is Pectin?
The cell wall of plants is a polysaccharide and protein rich macromolecular structure that is essential for plant form and function. It is also the meeting point between the plant and its symbionts or pathogens. Pectin is a major…
Research in the Moremen lab focuses on the structure, regulation, and localization of enzymes involved in the biosynthesis, recognition, and catabolism of mammalian glycoproteins. Carbohydrate structures on glycoproteins contribute to many biological recognition events during development, oncogenic…
The primary focus of the Pierce laboratory centers on understanding the regulation of intercellular recognition and adhesion, particularly those events that involve protein-oligosaccharide interactions. Almost 20 years ago, observations were made that when vertebrate cells became oncogenically…
We are using biochemical, cell biological, genetic, and molecular approaches in conjunction with the yeast system to better understand the function of enzymes involved in the production of isoprenylated proteins. Examples of isoprenylated proteins include the Ras family of oncoproteins, Ras-related…
Our research focuses on protein structure and function and protein-protein interactions. We employ an approach combining modern analytical, biophysical and molecular biology techniques, with an emphasis on biomolecular NMR spectroscopy. Our core projects include the study of gene regulation and…
Our primary research interest is to understand the role and the underlying mechanisms of heparan sulfate proteoglycans in angiogenesis, stem cell, hemostasis and leukoctye trafficking/inflammation with a long-term goal to develop novel therapeutics to improve the treatment of vascular diseases such…
Functional diversity increases as you go from DNA to RNA to Proteins. The concept of one gene encodes one gene product is no longer valid. One of the principle ways that diversity is increased is through post-translational modifications of proteins.
Using a combination of methodologies, including…
My lab is using experimental and computational approaches to study genomic and epigenomic changes occurring during cancer initiation and progression, as well as during normal biological processes such as mammalian genome evolution and cell differentiation. The goal is to understand the roles of…