We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work. Our current efforts are focused on protein kinases, a large and diverse family of enzymes that propagate cellular signals through the controlled phosphorylation of protein and small molecule substrates. We are using a combination of computational and experimental approaches to understand how natural sequence variation contributes to functional variation in protein kinases, and how non-natural variation contributes to disease.

Click the following link to learn more about our ongoing research projects.