The research in the Adams Laboratory focuses on the physiology of hyperthermophilic organisms with an emphasis on metal-containing enzymes in the hyperthermophilic marine archaeon Pyrococcus furiosus.
Researchers in the Adang's laboratory are involved in insect molecular investigations which will facilitate the long-term use of the insecticidal bacterium Bacillus thuringiensis for insect pest control
We are an interdisciplinary research group at the interface of carbohydrate research and immunology. Our objective is to explore treatment of and protection from infectious diseases and cancer by understanding key molecular and cellular interactions between the components of the immune system and carbohydrate antigens associated with microbes or cancers.
Our research program is directed at: delineating immune mechanisms involved in carbohydrate-mediated adaptive immune response, and designing, synthesizing and testing vaccine targets against model pathogens and cancers. Our research approach involves: (1) identification of the molecular interactions involved in uptake, processing and presentation of carbohydrate antigens by the antigen presenting cells (APCs), (2) isolation and characterization of T cells and their epitopes generated from model carbohydrate antigens, (3) understanding the basis for cellular and humoral immune responses induced by carbohydrate presentation and recognition that enable eradication of disease causing agents, (4) design and synthesis of new-generation therapeutic and/ or prophylactic agents based on the knowledge gained from mechanisms discovered.
The Bioexpression and Fermentation Facility (BFF) consists of 4 core laboratories, the Fermentation Research Facility (FRF), Protein Purification Facility (PPF), Monoclonal Antibody Facility (MAF), and Cell Culture Facility (CCF).
The Dailey lab’s research focuses on the enzymes responsible for heme biosynthesis.
Our work focuses on the generation of therapeutically useful cell types that can be used to treat cardiovascular disease, diabetes, stroke, autoimmune disease, spinal cord injury and neurological diseases. We are also interested in early development and how pluripotent cells contribute to the developing embryo.
Darvill's research focuses on structurally characterizing the five major noncellulosic carbohydrates of plant primary cell walls homogalacturonan, rhamnogalacturonan I and II, xyloglucan, and glucuronoarabinoxylan.
Research is being conducted on normal and various human cancer cell lines to determine whether glucose metabolism can be inhibited. Such inhibitors can serve as supplementary chemotherapy reagents.
Research in the Garfinkel Laboratory addresses the mechanism and consequences of retrovirus-like transposon movement in Saccharomyces.
My laboratory is mainly interested in the molecular and biochemical basis of parasitic diseases. We are currently investigating several basic molecular pathways in African trypanosomes.
We study how protein glycosylation affects cellular communication as well as protein folding using biochemical, cell biological and animal studies. The forms of glycosylation we study affect development, birth defects, and cancer.
The primary goal of our research is to understand the molecular basis of self-renewal and differentiation in normal and cancer stem cells.
We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work.
A broad description of the work being performed in this laboratory would include the mechanisms of metalloproteins involved in radical generation, heme synthesis, as well as the mechanisms of heme sensing, aquisition and transport.
My group studies problem solving among undergraduate students in biology and biochemistry. We also research how to support college instructors who attempt to incorporate case study teaching into their courses.
The work in my laboratory deals with the biosynthesis of heme and it regulation.
The main research project in the Mohnen laboratory is based on the premise that the most direct way to elucidate the biological functions of pectin is to understand how pectin is biosynthesized. The bulk of our research examines how the pectic polysaccharide homogalacturonan (HGA) is synthesized.
Research in the Moremen lab focuses on the structure, regulation, and localization of enzymes involved in the biosynthesis, recognition, and catabolism of mammalian glycoproteins.
Dr. Orlando conducts research on using mass spectrometry (MS) to answer biological questions.
The primary focus of the Pierce laboratory centers on understanding the regulation of intercellular recognition and adhesion, particularly those events that involve protein-oligosaccharide interactions.
Research in the Prestegard laboratory focuses on nuclear magnetic resonance (NMR) methods development and application of those methods to challenging problems involving soluble proteins, membrane proteins, cell-surface carbohydrates, and carbohydrate-protein interactions.
X-ray structural biology, protein structure determination by Native-SAD, structural investigation of components the mitochondrial inner membrane space transport system, structure based vaccine and therapeutic design.
The current research focus of the lab concerns on the function of a novel modified DNA base, called base J, on the regulation of VSG gene expression.
We are using biochemical, cell biological, genetic, and molecular approaches in conjunction with the yeast system to better understand the function of several proteases that act on isoprenylated proteins.
The Scott group conducts research in the general areas of biophysical chemistry. Major current research projects include the use of X-ray absorption spectroscopy to study the structure of metals in biological systems, including metal binding sites in metallosensors and metalloregulators, as well as study of the metalloproteome.
We study disease mechanisms in cartialge and the nervous system using zebrafish models of inherited human disorders. Our lab is also using chemical biology approaches to address how lysosomal storage alters glycoprotein trafficking.
We study RNA-driven biological pathways with the goal of improving the understanding and treatment of human disease, and advancing biotechnology and industrial applications.
We utilize genetic, molecular, and chemical techniques in vertebrate (mouse) and insect (Drosophila) model systems to study two aspects of carbohydrate expression.
Our research focuses on protein structure and function and protein-protein interactions. We employ an approach combining modern analytical, biophysical and molecular biology techniques, with an emphasis on biomolecular NMR spectroscopy.
Development of advanced instrumentation for diffraction studies including synchrotron X-ray sources, remote access for beamline operations, robotic sample mounting technologies, and in-house X-ray sources.
Our primary research interest is to understand the role and the underlying mechanisms of heparan sulfate proteoglycans in angiogenesis, stem cell, hemostasis and leukoctye trafficking/inflammation with a long-term goal to develop novel therapeutics to improve the treatment of vascular diseases such as ischemia and stroke, inflamation and cancer et al.
Functional diversity increases as you go from DNA to RNA to Proteins. The concept of one gene encodes one gene product is no longer valid. One of the principle ways that diversity is increased is through post-translational modifications of proteins.
Glycobiology of protozoa, including traditional and novel forms of protein glycosylation. Our specialization is the role of a complex form of hydroxyproline-dependent cytoplasmic glycosylation on polyubiquitin ligase activities and oxygen sensing.
My lab studies the relationship between protein structure and function, and specifically how enzyme activity is regulated.
Research in the Woods group examines the relationship between carbohydrate conformation and biological recognition.
Our group's research and development center around the following areas:
Dr. York's diverse research interests include the development and application of spectroscopic and computational methods for the structural and conformational analysis of complex carbohydrates, the development of bioinformatics tools to study the roles of carbohydrates in living systems, and the use of these tools to develop realistic models describing the assembly and morphogenesis of the "primary cell walls" that surround the growing cells of higher plants.
My lab is using experimental and computational approaches to study genomic and epigenomic changes occurring during cancer initiation and progression, as well as during normal biological processes such as mammalian genome evolution and cell differentiation.